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  • Thalidomide: What is it?

    Thalidomide was originally created in Germany to be a non-addictive sedative with a lower risk of dependency for sleep. The drug became popular because it was a morning sickness reprieve that was over the counter and affordable. This drug had an unforeseen effect on fetuses. It caused an influx of miscarriages and congenial mutations. One of the mutations is “the hands and feet are bound to the child’s trunk, absent or underdeveloped” ( Fact Check-FDA did not approve thalidomide for pregnant women in 1950s or 1960s). Other mutations include ocular, auricular, and internal organ mutations. Children unborn and born suffered the effects of Thalidomide. “An estimated 80,000 fetuses had mutations, and 20,000 more who survived were born without limbs” (1). These connections were not found until a significant amount of children were born. Thalidomide was not safe for pregnant women, but we did not find that out until Thalidomide submitted an application to the FDA for the drug to be approved in America.

     

     

    FDA not approved!

    This was Frances Kelsey’s second NDA case, meaning she didn’t yet have a backlog of reviews to get through. She dismissed physicians’ testimonies in favor of actual scientific evidence. She asked for more information from the developer, but they responded with another application. Knowing that thalidomide causes neurological toxicity in adults, she was wary of what effect it would have on human fetuses. Kelsey kept digging and stalled the FDA’s approval (McNeill). There have been no mutations caused by Thalidomide in the US because of Kelsey’s thoroughness. “Kelsey received the President’s Award for Distinguished Federal Civilian Service for her work in protecting the public from the drug.” (1) This very public case increased the basic testing done on pharmaceuticals so much so that “the 1962 drug amendments bill passed that year to change drug regulation” (1). Through Kelsey’s discretion, the US has more regulation and testing required for FDA approval saving countless lives. Thalidomide is not a very safe drug to use and many have suffered because of it, however it’s creation led to the FDA bolstering their requirements for our future.

     

    Other Uses!

    In general, Thalidomide helps prevent skin symptoms, nerve damage caused by leprosy, and blocks certain natural substances that cause swelling. Some more uses for Thalidomide is that it treats certain complications of HIV, HIV-associated diarrhea, HIV-associated wasting syndrome, a type of skin cancer. It also treats multiple myeloma by strengthening the immune system to fight cancer cells (Thalidomide: Medlineplus Drug Information). Thalidomide has also been used to treat some types of cancer and tumors, severe weight loss in patients with weakened immune systems, chronic graft versus host disease, and Crohn’s disease (4). A side effect in using Thalidomide to treat cancer is damage to nerves in the fingers and toes. There may also be blood clots, drowsiness, rashes, or dizziness. Some “Doctors found that it helps regulate the body’s immune system and helps control inflammation” (Thalidomide: Research advances in cancer and other conditions). The risks associated with Thalidomide are very high, therefore they must match the risks of illness to be treated.

     

    Creating a safer Thalidomide!

    Thalidomide has some benefits for other illnesses, which led to the investigation and creation of drugs that were safer. Two chemically similar drugs are Revlimid and Pomalidomide (Pomalyst). “Pomalidomide is the generic name for the trade name chemotherapy drug Pomalyst ” (Cancer, Cleveland Clinic). There are normally no side effects with this Pomalidomide and if there are side effects, they are reversible and stop when the treatment stops (5). It should never be taken during pregnancy, just like thalidomide. What causes this drug to work against cancerous cells is unknown. It may act by inhibiting the growth of new blood vessels in tumors, enhancing the immune system, or decreasing cytokine and growth factor production (5). Pomalidomide lowers the risks and side effects of Thalidomide. Revlimid is an oral cancer drug that is used for the treatment of multiple myeloma, myelodysplastic syndrome, and mantle cell lymphoma (Revlimid Drug Information: The MMRF). It works against cancer cells partly by supporting the immune system. Revlimid side effects are reversible and has a clearer treatment process, but it has fewer uses. Pomalidomide is effective for many things, however it is not known how it helps decrease cancerous cells. There are pros and cons to both medications, but they are safer than Thalidomide. Thalidomide had an extremely negative effect on the world, but Thalidomide’s errors led to safer regulations and more scientific advancements.

    Bibliography

    1. “Fact Check-FDA Did Not Approve Thalidomide for Pregnant Women in 1950s or 1960s.” Reuters, Thomson Reuters, 27 Aug. 2021, https://www.reuters.com/article/factcheck-thalidomide-fda/fact-check-fda-did-not-approve-thalidomide-for-pregnant-women-in-1950s-or-1960s-idUSL1N2PY2F7. \
    2. “Thalidomide: Research Advances in Cancer and … – Mayo Clinic.” Thalidomide: Research Advances in Cancer and Other Conditions, 3 July 2021, https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/thalidomide/art-20046534. 
    3. McNeill, Leila. “The Woman Who Stood between America and a Generation of ‘Thalidomide Babies’.” Smithsonian.com, Smithsonian Institution, 8 May 2017, https://www.smithsonianmag.com/science-nature/woman-who-stood-between-america-and-epidemic-birth-defects-180963165/. 
    4. “Thalidomide: Medlineplus Drug Information.” MedlinePlus, U.S. National Library of Medicine, 15 Aug. 2009, https://medlineplus.gov/druginfo/meds/a699032.html. 
    5. Cancer, Cleveland Clinic. “Pomalidomide.” Pomalidomide | Chemotherapy Drug Information | Chemocare.com, https://chemocare.com/chemotherapy/drug-info/pomalidomide.aspx. 
    6. “Revlimid Drug Information: The MMRF.” Themmrf.org, 10 June 2020, https://themmrf.org/multiple-myeloma/treatment-options/standard-treatments/revlimid/#:~:text=Revlimid%2C%20also%20known%20as%20lenalidomide,Revlimid%20is%20manufactured%20by%20Celgene. 
    April 27, 2022
  • Anima-Toons! Baby Fever

    Anima-Toons! Baby Fever

    Anima-Toons! Baby Fever

    Did you know that a newborn kangaroo is the size of a lima bean and that echidnas lay eggs because these two sure didn’t.

    April 27, 2022
  • Why Laughing at Memes With Friends is Good For You

    Why Laughing at Memes With Friends is Good For You

    You find a funny meme on the Internet. You chuckle to yourself and decide to show your friend. They start giggling which makes you only laugh harder. Your friend picks up on this and their laughter dials up and now you two are in a symphony of hilarity and you wonder if the little meme was even that funny to begin with.

    Why do we laugh, and why do we seem to laugh more around others? Well secret’s out, you’re wired to do so just like chimpanzees are wired to groom each other.

     

    Are Laugh Tracks… actually useful?

    Laughter plays a key role in social communication. It’s a human’s way of expressing they want to connect with others, and it can reveal how close those connections are. In a 2001 Psychological Science study, voiced laughter (think of your typical hahahaha) was reported to invoke a more positive reaction out of the listener and prompt them to be interested in meeting the speaker. We laugh to seem approachable and bond with others. That’s also why people are 30 times more likely to laugh in a group than to laugh alone regardless of how funny the actual joke is. The laugh track of older TV series mimics sitting in a social situation with other people watching the show to try to make the experience more enjoyable. 

    Not all laughter is the same though. People can pick up the subtle mannerisms of laughter and what those differences might mean. For example, a 2016 international study showed that 60% of the time people accurately can differentiate whether or not two individuals were good friends or strangers just by their laughs (So yes, you awkwardly strain laughing at a coworker’s joke does not always go unnoticed). Laughter can also distinguish power hierarchy between two individuals based on whether the person has a dominant or submissive laugh in the situations. Those with more power in a social situation will have a dominant laugh that is louder and possesses much more irregularities in pitch and tone than a submissive laugh, as the person in power feels more disinhibited during the situation.

    Even though you might never mutter a word when you laugh, you’re still subtly communicating and bonding with others. 

     

    Laughter is the Best Medicine. No Really.

    Is the social element of laughter not your cup of tea? There’s plenty of health-related benefits to laughing too. Laughing can:

    • Reduce stress by releasing tension in the body and helping blood to circulate and muscles to relax.
    • Improve mood through releasing endorphins
    • Increase your intake of oxygen 

     

    So not only are you improving your social status with laughter, but you’re strengthening your body too. Don’t feel afraid to laugh it up with someone next time! Even if it’s at some dumb meme on the Internet.

    Citations

    Mayo Foundation for Medical Education and Research. (2021, July 29). Stress relief from laughter? it’s no joke. Mayo Clinic. Retrieved April 26, 2022, from https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress-relief/art-20044456

    Michel, A. (2017, March 31). The science of humor is no laughing matter. Association for Psychological Science – APS. https://www.psychologicalscience.org/observer/the-science-of-humor-is-no-laughing-matter

    Stierwalt, S. (2020, February 9). Why do we laugh? Scientific American. https://www.scientificamerican.com/article/why-do-we-laugh/

    Winerman, L. (2006, June). A laughing matter. Monitor on Psychology, 37(7). https://www.apa.org/monitor/jun06/laughing
    April 27, 2022
  • Bananas Are Dying. Again.

    Bananas Are Dying. Again.

    You’ve probably eaten a banana before. You’ve probably even eaten one this week in a smoothie, in a baked good, or just by itself for a quick snack or breakfast. Bananas are a titan amongst the agricultural industry with a retail value between $20-25 billion dollars, making them a vital part of the economies of many Latin American countries like Panama and Ecuador.

    What you probably don’t know is that pretty much every single banana you’ve ever eaten is from the same variant, the Cavendish. These delicious plants replaced the Gros Michel, or Big Mike, banana as the star of the banana industry back in the 1960s when the Big Mike went nearly extinct. However, history is repeating itself and now the Cavendish banana is on the chopping block all due to the same reason: Fusarium wilt, or Panama disease.

    An Old Foe Returns for Revenge

    Fusarium wilt is a fungi that completely ravishes the soil and plants it touches. When affecting a plant, the fungi goes around 10 feet deep into the soil making it so that just removing a single affected plant to stop the spread is nearly impossible. Large areas of soil become barren, and the fungi can be easily tracked to other places on the bottom of other workers’ shoes or car tires. Tropical Race 1 of this disease began killing Gros Michel in large quantities in the early 20th century, so the resistant Cavendish took its place in the industry; however, now the Tropical Race 4 variant (TR4) has crumbled the Cavendish’s resistance.

    The deadliness of TR4 has only been heightened by the monoculture system of the banana industry. Since nearly every banana sold commercially is the Cavendish, a variant without seeds for easier consumption, Cavendish bananas must be propagated from existing growths causing them to be near genetic copies of one another. This small gene pool decreases the Cavendish’s resistance to diseases like TR4 and once one banana plant is affected, it can easily spread to other batches and destroy new ones.

    Stop the Spread!

    Can the Cavendish banana be saved or will it fall to the same fate as its predecessor, Big Mike? There have been a couple of attempts to solve the issue at hand with varying degrees of success:

    • Genetically Modified Cavendish: In 2019, Dr. James Dale successfully modified a batch of Cavendish bananas with a gene from a TR4-resistant banana. However, the fear and bans of GMOs in many countries has kept this from becoming an appealing solution.
    • Breeding Cavendish with resistant bananas: KeyGene has been attempting to traditionally breed a Cavendish with a resistant banana to try to get around the GMO dilemma. However, these resistant bananas tend to be inedible ones full of seeds, and through traditional breeding, it is difficult to get the exact results desired to produce a delicious yet TR4 disease-resistant banana.
    • Diversify the banana industry: Breaking free of monoculture to grow and sell multiple kinds of bananas would make it much more difficult for an entire breed to be fully wiped out like Big Mike was. However, the banana industry is completely modeled around monoculture and to change this would need a large sum of money and structural alterations that companies are not willing to make at this moment.
    • Biosecurity protocol: This is the one solution currently being used by most banana farms. Areas where an affected plant has been identified will be zoned off and destroyed. Workers must also walk along cement paths and utilize foot and car tire washing areas to try to diminish possible contaminated soil tracking to other locations. These measures have been working so far as to slow the spread of TR4.

     

    There is still a lot of uncertainty with the Cavendish banana’s future, and one day, you might not be able to taste it again. Cherish each banana you eat because just like you, they’re surviving through a pandemic right now too!

     

    Citations

    Abby Narishkin, S. C. (2021, July 29). Why the world’s favorite banana may go extinct, and how scientists are trying to save it. Business Insider. https://www.businessinsider.com/cavendish-banana-may-go-extinct-disease-2021-6#:~:text=Similar%20to%20humans%2C%20bananas%20are,the%20%2425%20billion%20banana%20industry.

    Kambhampaty, A. P. (2019, November 18). What we can learn from the near-extinction of bananas. Time. https://time.com/5730790/banana-panama-disease/

     

    April 27, 2022
  • To Vibe or Not to Vibe

    To Vibe or Not to Vibe

    We’ve all been there: your friends pass you the aux cord at a party and you play your favorite songs only to be met with sighs and groans or –even worse– silence. These are some bangin’ tunes that make you smile. Why do others find those same songs to be boring or “not their cup of tea?” When we like a certain song, dopamine is released into the brain and makes us feel happy or euphoric. This causes us to like a song a little more than your friends and makes you want to listen to more songs in that genre. But what causes our brain to release this chemical? Psychology may provide the answer regarding the inner machinations of the human mind. 

    Jon Lieff, MD via grok.com.au

    Our Emotions:

    Music affects us in three major ways: it serves as a nice distraction, stimulates internal curiosity, and can affect our emotional state. For example, people might listen to music to destress or have as background noise– meanwhile, other people could use those same songs to hype themselves up for a workout. These differences lead us to choosing different genres and songs.

    Music is also interpretive and allows us to choose our own meaning and significance for a certain song. This subjectivity allows different people to determine that in different ways. The same line that means nothing to you may make your friend very emotional. Take your favorite song: is there any reason why you really appreciate the song? Do you associate an emotion with the song? This may be a reason as to why there isn’t a favorite universal genre or song. Since music typically appeals to the emotions, people may associate a certain feeling with a song and grow attached to it. For instance, some of my favorite songs are those that I’ve listened to with my friends and raved about or the ones that my former piano teacher introduced me to. 

    Identity:

    In addition to personal emotions, our perceptions of others and ourselves also influences our taste in music. People have often used music as a way to express themselves and their identity. Because of that, people have associated some songs with certain archetypes of people. According to one study that asked participants to map certain traits to genres, they associate genres like pop and country were more extroverted. On the other hand, jazz and classical were thought of as more reflective.

    ResearchGate, 2016

    Culture:

    Our preferences for certain songs may also be cultural. If we’re exposed to a lot of a certain type of music, we may lean towards more songs that contain those same elements. There are two forms of chords: consonant and dissonant. Consonant chords contain frequencies that are different enough that they don’t seem to clash. Meanwhile, dissonant chords sound a bit more chaotic for lack of better terms. Western music (like pop) usually contains a lot of consonant chords, and Americans have a strong preference for these sounds. However, some other cultures do not show that same, strong preference.

    Statistica 2021

    Whether it be because of what we were exposed to growing up or our self-identity, music tends to distinguish us from others. Although not much research has been done to see if it is truly connected to our personalities, we still manage to label people according to the music they listen to. Perhaps the real question is if the songs we vibe to influences if people vibe with us.

    Resources:

    Anne Trafton, Anne. “Why We like the Music We Do.” MIT News | Massachusetts Institute of Technology, Massachusetts Institute of Technology, 13 July 2016, https://news.mit.edu/2016/music-tastes-cultural-not-hardwired-brain-0713.

    Chamorro-Premuzic, TomasPsychology. “The Psychology of Musical Preferences | Psychology Today.” Psychology Today, 14 Jan. 2011, https://www.psychologytoday.com/us/blog/mr-personality/201101/the-psychology-musical-preferences.

    Clark, Katelyn, et al. “Why Do We like (or Dislike) Certain Music?” Grok, 30 Jan. 2021, https://grokonline.com.au/2021/01/31/why-do-we-like-or-dislike-certain-music/.

    April 26, 2022
  • The Sound of Calm

    The Sound of Calm

    This meme made the rounds on the internet, claiming that a song can significantly reduce anxiety.

    The song was even named one of Time Magazine’s 50 top inventions of 2011, quoting,

    “Could this be the sleeping pill of the future? British ambient band Marconi Union has drummed up the world’s most relaxing song: “Weightless” is 8 min. 10 sec. of aural bliss, proved to reduce anxiety by 65% and slow heart rates by 35% as the listener’s body rhythm syncs with the song’s. Indeed, “Weightless” is so successful at inducing somnolence that scientists caution drivers not to listen to it while behind the wheel.”

    What is cortisol?

    Cortisol is a hormone released when your evolutionary stress response is triggered. 

    A release of cortisol means there will be more glucose in the bloodstream as well as substances that repair tissues, in case of a threat. Cortisol also suppresses the digestive and reproductive systems so that those do not impede you when you are facing an “enemy.”

    Can music really affect blood pressure and cortisol levels?

    One study from Deutsches Arzteblatt International found that listening to classical music actually did reduce blood pressure and cortisol levels in all participants, so music specifically engineered to calm people down from a state of anxiety could very well achieve its claims.

    Another study analyzed the song Weightless specifically, finding that “‘Weightless’ by Marconi was able to induce greater relaxation levels in participants than a massage (increase of 6%). ‘Weightless’ also induced an 11% increase in relaxation over all other relaxing music tracks.” (British Academy of Sound Therapy).

    The song has even apparently been used to calm patients before surgery, in a study published in the journal Regional Anaesthesia & Pain Medicine journal that showed that the song was just as effective as a anxiety-relieving drug.

    It might be worth it to give the song a listen the next time you feel anxious and stressed!

    What is Sound Therapy?

    The band Marconi Union worked with sound therapists to formulate as calm of a sound as possible, but what is a sound therapist?

    Sound therapy is another trend that is takes inspiration from ancient rituals, with dubious scientific backing. Therapists guide patients with individual tones or music, along with controlled breathing, to elicit an energetic or calmed emotional response. “Common sound therapy instruments include Tibetan sound bowls, crystal bowls, gongs, tuning forks, chimes, and voice. Sounds can also be pre-recorded, like white noise, ambient music, or guided instructions. ” (Prevention.com)

    Sound therapy has been compared to a massage, where instead of a practitioner’s hands, the vibration of the sounds produce the sensations. 

    A research study titled, “Sound Therapy Induced Relaxation: Down Regulating Stress Processes and Pathologies,” outlines a proposition that nitric oxide produced in the body when undergoing sound therapy is responsible for the physiological effects in the body, providing a potential scientific basis for how sound therapy could be effective.

    Even a quick YouTube search shows that videos claiming to be sounds appropriate for sound therapy have millions of views.

    While it seems unlikely that sound therapy could be a significant treatment for mental illness, in combination with other therapy it may be a viable option, due to its non-invasive and accessible nature.

    References

    • https://web.archive.org/web/20120220013121/http:/www.time.com/time/magazine/article/0,9171,2099708-4,00.html
    • https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20046037
    • https://www.independent.co.uk/arts-entertainment/music/news/relaxing-song-best-weightless-marconi-union-youtube-surgery-anxiety-a9011971.html
    • https://www.prevention.com/health/mental-health/a30986834/what-is-sound-therapy/
    • https://lbdtools.com/resources/Reference_PDFs/SoundTherapyInducedRelaxation.pdf
    • https://africacheck.org/fact-checks/fbchecks/yes-studies-have-found-instrumental-songs-weightless-can-reduce-anxiety
    • https://www.britishacademyofsoundtherapy.com/wp-content/uploads/2019/10/Mindlab-Report-Weightless-Radox-Spa.pdf
    • https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/behind-the-headlines/music-and-blood-pressure
    • https://www.independent.co.uk/news/health/music-therapy-surgery-anxiety-operation-sedative-a9010701.html 

     

     

    April 26, 2022
  • Would a Victorian-era child survive the miracles of the modern day?

    Would a Victorian-era child survive the miracles of the modern day?

    You’ve probably seen memes about Victorian children not being able to survive drinking a McDonald’s Sprite because it’s so fizzy, or eating a spoonful of Taki powder because it’s too spicy, the Victorian era spanning the majority of the 19th century. If you haven’t, well, it’s a common joke online to say that a Victorian child couldn’t survive the wonders the modern era has to offer, whether it be a very spicy snack or loud music like heavy metal. What exactly is the reasoning behind saying that? It’s sparked debate online: most people believe that a Victorian-era child would not survive consuming a lot of modern-day food, while a handful argue that if those children could survive unsanitary conditions, they could survive eating a spicy chip today. But what would actually happen? Since the Victorian age, we’ve made some clear medical progress and we’ve also evolved further as humans. Let’s take a deeper look into how humans have evolved biologically since the Victorian era and finally answer the question: would a Victorian-era child survive the miracles of the modern day? 

    Historically, the average life expectancy for a newborn infant in the 19th century was 41 years, whereas in 2021, it was 79 years. What this means is that anyone born in 2021 is expected to live almost twice as long as someone born in the Victorian era, for a multitude of reasons. The primary reason for such a low life expectancy was because infant mortality rate was very high; many infants would not live to their first birthday, significantly dropping the overall life expectancy. Lower class children were usually forced into labor that entailed dangerous working conditions that would often result in a multitude of health conditions and deaths. Public health was not as advanced back then as it is now, so people who contracted diseases were mostly likely to succumb to their illness. 

    In fact, the medicine of this era was a concoction of drugs that would not be found in normal medicine today, like cocaine, morphine and opium. Morphine could be found in soothing syrups, while opium was widely used for treating coughing and diarrhea. Many children would often die as a result of consuming this medicine, and those who didn’t would most likely develop an addiction to it. Many of these medicines would lead to serious medical complications, such as destruction of the teeth and jaws and organ damage.

    Another factor to consider in this debate is the type of food consumed in the Victorian era. Most people in this time period depended on seasonal crops, and the food for the working class was often lacking in flavor. Most of their meals were fruits and  vegetables available in that season and were usually accompanied with bread. Meat was expensive for poor families, while middle and upper class families could indulge in imported foods that contained sugar and coffee. As a result, most of the food was rather bland as seasonings were more of a luxury. Most meals were accompanied with low alcohol beer, as beer tended to be cleaner than the water available. 

    All that being said, let’s finally answer the big question. Today’s foods tend to be very processed and contain a variety of different chemical preservatives to ensure it lasts longer.  Realistically, a Victorian child would not die from eating a Taki. However, that doesn’t mean they’d be perfectly okay after consuming modern-day food. Today’s food would contain a large amount of unfamiliar bacteria that would most likely lead to stomach issues, and in the long run, if consumed regularly, death. Victorian children already had weakened immune systems, so consuming something that contains a lot of chemicals would worsen their condition. Prolonged consumption of modern-day food would surely lead to major health issues if not death. Additionally, one serving of modern-day would probably cause a lot of stomach issues due to gastric distress from unfamiliar seasonings and excess sugar. Modern age food is prepared for modern taste, and it’s important to remember that the average Victorian child didn’t consume heavily seasoned food. So while it’s funny to think about it, one single serving of modern-day food would not kill a Victorian child. It’s a different story if they’re eating it regularly, but one serving would at most lead to an upset stomach. 

     

    Sources:

    • https://www.dailymail.co.uk/news/article-3228085/How-live-TWICE-long-Victorians-growing-life-expectancy-means-pensions-run-out.html
    • https://www.webmd.com/a-to-z-guides/features/look-back-old-time-medicines
    • https://backinthedayof.co.uk/food-in-the-victorian-era
    April 23, 2022
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