Ain’t No Sunshine When She’s Gone

Frazer_Park_(Portland,_Oregon)Before I moved away from Florida I never realized how much I depended on good weather to motivate me.  I’d always believed that optimism and happiness came from within, but now I know this is only half true.  Moving to an area that gets less sunshine than from where you came from is a real downer.  Atlanta gets a relatively median amount of sunshine per year (compare Atlanta GA at ~217 days; Tampa FL at ~244 days; Seattle WA at ~164 days) but the pitiful winter here harbors few sunny days.  Gray skies can last for 3 days straight, the harsh cold wind is relentless, and February seems like the longest month of the year despite having the least amount of days.

What bugs me most is that threatening clouds hover over the city for days but never DO ANYTHING.  At least in Florida when clouds come, they produce rain, thunder and lightning for an hour, then get the hell out and the ordeal is over.  But here, when the weather wants to be gloomy, it’s taking you down too.  It doesn’t help when my family, still in Florida, tells me they’ve taken the boat out every weekend since the beginning of February.

It’s amazing how the weather can be a source of depression.  I’m sure you’ve heard of seasonal depression, which is technically called Seasonal Affective Disorder.  If you haven’t, it is a type of depression that occurs when bright light and sunshine is limited, most often during the winter months.  Sunshine is the obvious treatment for the disorder but just how effective is sunshine?  Especially when every dermatologist and health magazine advises you to block the sun?

Studies have shown that the brain produces more of the natural antidepressant serotonin on sunny days than on darker days.  This is regardless of the season.  Not only are serotonin levels higher on bright days than on overcast ones, but the rate of serotonin production is directly related to the duration of bright sunlight.  No other atmospheric conditions are related to serotonin levels (article from WebMD Health News).

When sunlight interacts with our skin, Vitamin D is produced through photochemical reactions.  Of course, prolonged UV exposure can be harmful for your skin, but some exposure is extremely beneficial.  (DO: Be active in sunlight when possible, with at least 25 SPF on.  DO NOT: Lay by the beach all day without lotion).  Vitamin D works together with calcium to build strong bones and maintain bone strength.   It also has a preventative effect for some cancers including colon, breast, ovarian and prostate.  A deficiency in Vitamin D is linked to these types of cancer as well as to depression, lowered immunity, osteoporosis, and arthritis.

You might have been aware that sunshine was positive for you, but here are some fun facts that maybe you didn’t know:

  • According to Healthkicker, people tend to buy more lottery tickets on cloudy days because weather-induced bad moods deplete self control, making us vulnerable to temptation.  (Ladies, think Ben & Jerry’s ice cream pint intakes – were those ever on bright sunny days?)
  • People use more alcohol, coffee, tobacco and chocolate when there’s less sunshine because they feel the need to compensate artificially as means to elevating their mood.
  • Getting a daily dose of sunshine increases your number of white blood cells, which in turn enhances your immune system, stated by Natural Health Restored.
  • Sunshine encourages healthy circulation by also stimulating the production of red blood cells, which increases the amount of oxygen in your blood.
  • A study performed at the University of Michigan proved that sunshine is strongly correlated with daily stock returns.  Stocks traded on sunny days yielded nearly 25% more money than those traded during cloudy periods.  Psychologists attribute this to people’s tendency to view situations more optimistically when it’s sunny, and less likely to scrutinize an investment they might cast aside when feeling grumpy.

March is only a few weeks away, which means warmer weather is coming.  Besides the fact that spring is my favorite season, I am SO excited to shed my layers of fuzzy clothes and to enjoy Atlanta’s parks again.  When the time comes, do yourself a favor and GET OUT of the library, frolic in the daylight like a fool high on Vitamin D and always wear some sunscreen!

In the spirit of things: [soundcloud url=”http://api.soundcloud.com/tracks/44617965″ params=”” width=” 100%” height=”166″ iframe=”true” /]

Photo by Maria Fiala courtesy of Creative Commons.

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  Timothy Durham was convicted of rape when a test showed his DNA genotype matched the DNA recovered from the crime scene. Eye witnesses testified that Durham was in a different state at the time of the incident, but he wasn’t exonerated from his 3000 year sentence until follow up DNA analysis showed that the preliminary forensic analysis used in the trial was misinterpreted (Thomas et al.). DNA testing serves an invaluable part in our criminal justice system, but it comes with complications and bias that can lead to wrongful convictions and misinformed juries.  

Background:

Forensic genetics aims to identify the origin of a biological sample. It can be traced back to Karl Landsteiner who discovered human ABO blood groups. With blood groups, suspects could be eliminated based on their blood type. For example, if a suspect had type A blood and there was type B blood left at the scene by the perpetrator, the investigators could rule out the suspect. Unfortunately, the reverse didn’t work. If the suspect and perpetrator both had the same blood type, it can’t be concluded that the suspect was guilty. Blood identifiers evolved into 8 distinct categories which improved the ability to eliminate suspects, but could only conclude that (if the system matched) it might be the perpetrator or this person might be related to the perpetrator (Jobling and Gill). The field evolved in the 1980s with the discovery of Minisatellites, lines of repetitive DNA that don’t encode proteins. Minisatellite patterns in DNA create what we know today as the DNA fingerprint, and it has a much higher accuracy rate than previous methods (Augustyn et al.). Around the same time, a breakthrough for victims of sexual assault was discovered. In the case of assault, bodily fluids of both the victim and the assaulter can get mixed. A process called differential lysis was created which could selectively increase the concentration of sperm in a fluid sample thereby allowing for accurate DNA testing (Jobling and Gill). Forensics evolved to use single-locus probe testing after several years because of its ease of interpretation. It looked at specific minisatellites that had high variability between subjects. This was the first DNA-based method to be used in a criminal investigation. Two murder homicides from several years apart were connected using DNA evidence. The evidence was then used to exonerate an innocent man, and the guilty party was found when he tried to evade mandatory DNA testing for all men in the small town. His guilt was then reinforced when the DNA profiles matched, and he gave a confession (Jobling and Gill). Finding DNA at a crime scene doesn’t guarantee that you’ll find a murderer. There are issues with non-pure samples and limited samples that make DNA work difficult, and accreditation of facilities and new techniques and take time (Jobling and Gill).  

Subjectivity of DNA Interpretation:

In a 2009 publication, the National Academy of Science discusses the possibility for subjective influence in lab based forensics. The interpretation bias happens in complex cases where, for example, there could be a mixture of DNA. A study published in 2011 looked specifically at this issue. A gang rape happened in Georgia, and the mixture in DNA from the case was used to prosecute one suspect after another suspect took a plea bargain to testify against him. With DNA mixtures, there are three possible conclusions: suspect excluded, suspect cannot be excluded, and inconclusive. If the suspect is excluded, it means that there’s little to no possibility that his DNA is part of the sample. If the suspect cannot be excluded, it means that there’s a possibility that his DNA is part of the sample. In the trial, the DNA examiners who knew the context of the case concluded that the suspect being prosecuted could not be excluded. The 2011 study gave the DNA evidence from this case and the DNA profiles of the suspects to 17 forensic examiners. These examiners had no context of the case, and they all worked independently. Of the 17, only 1 came to the same conclusion (suspect cannot be excluded) as the examiners who knew the context of the case. Twelve of the 17 concluded that the suspect who was prosecuted and convicted had no relation to the DNA found in the sample. Not only does this show that subjectivity occurs due to the context of the case, but the 17 examiners came up with different findings based on their past experiences meaning that not all DNA analysis is objective. Some organizations like the Scientific Working Group on DNA Analysis Methods say that quantitative statistical evidence should be presented with every categorical conclusion, but the US doesn’t require this (Dror and Hampikian).

False Positives:

There are two categories that cause wrongful identification in a DNA report: coincidental matches and false positives. Coincidental matches are DNA matches between two unrelated people. The probability of these matches is about 1 to 500,000 for white individuals and about 1 to 350,000 for black individuals. This small probability of coincidental matches makes people feel confident in DNA evidence. False positives, on the other hand, are matches between DNA and test DNA that result from issues in the forensics lab. There have been multiple cases of forensics labs accidentally switching victim and suspected rapist DNA which lead to convictions that were later overturned when the lab realized the error. There are also cases of misreading or misunderstanding a sample. In a case from 1993, a man was convicted of rape because someone interpreted a mixed sample of victim and perpetrator DNA as an individual sample. The conviction was again overturned. To prevent false convictions, retesting DNA is allowed, but it’s not an efficient solution. Many people are pushing for statistical information on the probability of false positives, so that the jurors can make accurate judgements based on DNA evidence (Thomas et al.).  

Conclusion:

DNA analysis is a useful tool for the criminal justice system, but subjectivity can be an issue in forensic testing. To combat wrongful convictions, there are organizations like The Innocence Project who use DNA testing to free the innocent, but reformed forensic testing standards should be put in place to prevent subjectivity and to ensure juries are correctly informed during trials. https://www.innocenceproject.org/    

Citation:

Augustyn , Adam, et al. “DNA Finerprinting.” Encyclopedia Britannica , 26 Apr. 2018, www.britannica.com/science/DNA-fingerprinting#ref153186. Dror, Itiel E., and Greg Hampikian. “Subjectivity and Bias in Forensic DNA Mixture Interpretation.” Science & Justice, vol. 51, no. 4, 2011, pp. 204–208., doi:10.1016/j.scijus.2011.08.004. Jobling, Mark A., and Peter Gill. “Encoded Evidence: DNA in Forensic Analysis.” Nature Reviews: Genetics, vol. 5, no. 10, Oct. 2004, pp. 739–751., doi:10.1038/nrg1455. Thompson, William C, et al. “How the Probability of a False Positive Affects the Value of DNA Evidence.” Journal of Forensic Sciences, vol. 48, no. 1, Jan. 2003, pp. 1–8., doi:10.1520/jfs2001171.